Study finds a possible biological cause for sudden infant death syndrome – Times of India
New Delhi: Researchers have found a mutated serotonin 2A/C receptor in infants who died of the disease. Sudden infant death syndrome (SIDS), a biological abnormality that they believe puts these infants at risk of death under certain circumstances.
SIDS is the unexplained death of an infant, usually in his sleep, before his first birthday Despite a thorough investigation into its cause.
Previous research in mice has shown 2A/C receptor signaling to play a role in arousal and autoresuscitation, which protects brain oxygenation status during sleep.
In the study, researchers, including those from Boston Children’s Hospital, Massachusetts, US, examined the brainstems of 70 infants who died between 2004 and 2011, and found consistent abnormalities.
They found that the serotonin 2A/C receptor was suddenly altered. Death of a child Cases versus control cases of infant mortality.
They published their findings in the Journal of Neuropathology and Experimental Neurology.
Investigators believe that the infant suddenly Death syndrome Occurs when three things happen together: a baby is in a critical period of cardiorespiratory development in its first year, the baby is exposed to external stressors such as a face-down sleeping position or bed-sharing, and The child has a biological abnormality that causes it. Risk of breathing problems while sleeping.
“The presented work mirrors previous work from our laboratory and demonstrates abnormalities in the serotonergic system of some SIDS infants.
“Although we have identified abnormalities in the serotonin 2A/C receptor in SIDS, the relationship between the abnormalities and the cause of death is unknown.
“Much work remains to determine the consequences of abnormalities in this receptor in the context of a larger network of serotonin and non-serotonin receptors that protect important functions in cardiovascular and respiratory control when challenged.
“Currently, we have no means of identifying infants with biological abnormalities in the serotonergic system. Thus, it is important to practice safe sleep practices,” said Robin Haynes, lead author of the paper.
SIDS is the unexplained death of an infant, usually in his sleep, before his first birthday Despite a thorough investigation into its cause.
Previous research in mice has shown 2A/C receptor signaling to play a role in arousal and autoresuscitation, which protects brain oxygenation status during sleep.
In the study, researchers, including those from Boston Children’s Hospital, Massachusetts, US, examined the brainstems of 70 infants who died between 2004 and 2011, and found consistent abnormalities.
They found that the serotonin 2A/C receptor was suddenly altered. Death of a child Cases versus control cases of infant mortality.
They published their findings in the Journal of Neuropathology and Experimental Neurology.
Investigators believe that the infant suddenly Death syndrome Occurs when three things happen together: a baby is in a critical period of cardiorespiratory development in its first year, the baby is exposed to external stressors such as a face-down sleeping position or bed-sharing, and The child has a biological abnormality that causes it. Risk of breathing problems while sleeping.
“The presented work mirrors previous work from our laboratory and demonstrates abnormalities in the serotonergic system of some SIDS infants.
“Although we have identified abnormalities in the serotonin 2A/C receptor in SIDS, the relationship between the abnormalities and the cause of death is unknown.
“Much work remains to determine the consequences of abnormalities in this receptor in the context of a larger network of serotonin and non-serotonin receptors that protect important functions in cardiovascular and respiratory control when challenged.
“Currently, we have no means of identifying infants with biological abnormalities in the serotonergic system. Thus, it is important to practice safe sleep practices,” said Robin Haynes, lead author of the paper.