Chronic lack of sleep may negatively affect our immune cells, raising certain health risks: New study
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According to a new study from the Icahn School of Medicine at Mount Sinai in New York City, losing an hour and a half of sleep every night on a regular basis can lead to inflammatory disorders and cardiovascular disease.
The study – published in the Journal of Experimental Medicine on Wednesday, September 21, 2022 – found that a Chronic lack of sleep Can affect a person’s immune cells and contribute to inflammation in the body.
Co-principal investigator Cameron McAlpine, Ph.D., assistant professor of medicine (cardiology) at Icahn Mount Sinai, told Fox News Digital, “Increased inflammation predisposes you to a whole bunch of problems, especially the heart. In the diseases of,” an interview.
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McAlpine is one of the researchers who participated in the new study.
“This work underscores the importance of getting seven to eight hours of uninterrupted sleep a day to help prevent inflammation and disease,” Philip Swirsky, PhD, director of the Cardiovascular Research Institute at Icahn Mount Sinai, said in a news release. Especially for those with underlying medical conditions.”
Adults need seven to eight hours of sleep a night, said the lead author of a new study, “to help prevent inflammation and disease, especially for those with underlying medical conditions.”
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The study begins to identify the mechanisms in the body that connect, the researchers said. Sleep and immunological health over the long term.
Research has shown that sleep disorders in humans and mice can affect cell programming and the rate of production of immune cells. Immune cells can then lose their effectiveness in protecting against disease.
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It can also affect the production rate of these cells and potentially make the infection worse.
“Another important observation [is that] that sleep reduces inflammation and conversely, sleep disruption increases inflammation.”
The researchers also found troubling evidence in mouse model studies that these effects may be long-lasting.
“This is important because it’s another important observation that sleep reduces inflammation and, conversely, sleep disruption increases inflammation,” Swirsky said in a news release.
McAlpine told Fox News Digital that the goal of the study was to better understand how chronic sleep disturbances can affect sleep. Cardiovascular conditions which develop over time due to inflammation.
A new study looked at the long-term effects of chronic sleep deprivation — compared to short-term sleep disruption over a few days.
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He said the findings could aid research into other inflammatory diseases and conditions in the body. such as arthritis.
The study looked at the long-term effects of chronic sleep deprivation, McAlpine said, compared to short-term sleep disruption over a few days.
The study helped identify biological mechanisms and pathways that link sleep and immune system health over the long term, he said.
The group of participants then cut their sleep time by 90 minutes each night for six weeks and had their blood drawn and reanalyzed.
The investigators looked at 14 healthy adults who slept eight hours a day.
Participants were first monitored as they slept at least eight hours a night for six weeks. The team of researchers took blood samples and analyzed the participants’ immune cells.
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The group of participants then cut their sleep time by 90 minutes each night for six weeks and had their blood drawn and reanalyzed.
According to the findings, all 14 participants in a new study had “significant changes” in their immune cells caused by sleep deprivation.
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The investigators compared blood samples and found that all 14 participants had significant changes in their immune cells that they attributed to lack of sleep.
Blood samples showed low sleep. Altered DNA structure and increased numbers of immune cells.
Normally, in an acute state of inflammation, the number of immune cells increases, health experts told Fox News Digital.
McAlpine also told Fox News Digital that the increased inflammation in mice that had fragmented sleep did not reverse after sleep was restored.
The researchers also looked at the effects of sleep disruption in mice.
In a rat model, groups of rats were allowed to sleep undisturbed, while another group was kept awake overnight for 16 weeks.
According to the report, mice in the disrupted sleep group underwent 10 weeks of uninterrupted sleep recovery.
“Our results suggest that sleep restoration is not able to completely reverse the effects of poor quality sleep. We can detect the molecular imprint of insufficient sleep in immune stem cells, even after weeks of restorative sleep. later too.”
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McAlpine said the research team analyzed immune stem cells and cells from groups of mice — and the results were consistent with human studies.
“We found it [both] Human and rat models [that] If you disrupt sleep, you increase inflammation in the blood.”
McAlpine also told Fox News Digital that the increased inflammation in mice that had fragmented sleep did not reverse after sleep was restored.
Not all stem cells respond to insufficient sleep in the same way, he said.
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“Unfortunately, in the human study, we didn’t assess recovery — but [we] observed recovery in rats. And in mice, we found that some parameters of inflammation returned to normal levels with sleep restoration – however, not all.”
Some cells remained (after sleep recovery) that made the mice more prone to inflammation, McAlpine said.
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In a news release, co-investigators said, “Our findings suggest that sleep rehabilitation is not able to completely reverse the effects of poor quality sleep. We detected a molecular imprint of insufficient sleep in immune stem cells. can, even after weeks. Restorative sleep. This … can cause cells to respond inappropriately, leading to inflammation and disease.”
McAlpine told Fox News Digital that the research team plans further studies to understand which genes are being affected by sleep — or the pathways of genes that may respond to sleep. This will help researchers understand the effects of sleep in more detail.